Article
Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation.
Molecular immunology - 1 Apr 1997
Tumas-Brundage K M, Vora K A, Manser T
Abstract excerpt
Previous work on the cis-acting elements that control heavy chain variable region (VH) gene somatic hypermutation has indicated the presence of an as yet unidentified element(s) 3' of the intron enhancer that is necessary for high rate mutation. Examination of cis-acting elements involved in kappa light chain V gene hypermutation has demonstrated a requirement for both the intronic and 3' kappa enhancers in this...
Topics
- Animals
- B-Lymphocytes
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Haptens
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred A
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nitrophenols
- Peyer's Patches
- Phenylacetates
- Transcription, Genetic