Article
Immunological abnormalities in BXSB mice at the onset of SLE development.
Journal of clinical & laboratory immunology - 1 May 1990
Morrison L J, Menzies C B, Behan W M, Behan P O
Abstract excerpt
Male BXSB mice develop murine lupus spontaneously at about 3 months of age. Polyclonal B-cell activation is thought to play a major role in the development of the syndrome in these mice, but the immunological events which lead to this activation are not known. We therefore examined the immune characteristics of mice aged 10-16 weeks, at the onset of disease. We found several immunological markers, indicating...
Topics
- Animals
- Antigen-Antibody Complex
- Autoantibodies
- B-Lymphocytes
- CD4-CD8 Ratio
- Complement Activation
- Disease Models, Animal
- Female
- Immunity, Cellular
- Lupus Erythematosus, Systemic
- Lymphocyte Activation