Article
Contractile properties of myocardium are altered in dystrophin-deficient mdx mice.
Journal of the neurological sciences - 1 Oct 1996
Sapp J L, Bobet J, Howlett S E
Abstract excerpt
The objective of this study was to determine whether cardiac contractile force is altered in the dystrophin-deficient mdx mouse model of muscular dystrophy. Left atria from 12-14-week-old control and mdx mice were paced at 1 Hz in 1.25 mM external Ca2+ buffer. Twitch properties and effects of interposing intervals of 0.3 to 600 s on the force of subsequent beats (force-interval curves) were examined. Peak force...
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