Article
[Pathological changes in heart activity of mdx mice and future prospects of mdx model in cardioimmunulogy].
Patologicheskaia fiziologiia i eksperimental'naia terapiia - 1 Jan 2000
Stenina M A, Savchuk V I, Krivov L I, Koval'chuk L V
Abstract excerpt
Dystrophin is a protein linking the cytoskeleton to a complex of transmembrane proteins that interact with the extracellular matrix. The fragility of the cardiomyocyte cell membrane resulting from the lack of dystrophin is thought to cause an excessive susceptibility to mechanical stress. Based on surface ECC we demonstrate the differences of cardiac phenotype in young (2- to 3-mo-old) and aged (over 1,5 years)...
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