Article
Altered Ca2+ sensitivity of tension in single skeletal muscle fibres from MyoD gene-inactivated mice.
The Journal of physiology - 1 Jun 1995
Metzger J M, Rudnicki M A, Westfall M V
Abstract excerpt
1. Single, fast glycolytic skeletal muscle fibres were isolated from wild-type (MyoD+/+) and MyoD mutant mice (MyoD-/-), which lack a functional copy of the MyoD gene. Fibres were chemically permeabilized to permit manipulation and control of the ionic environment of the otherwise intact myofilam...
Topics
- Animals
- Biomarkers
- Blotting, Western
- Calcium
- Contractile Proteins
- Electrophoresis, Polyacrylamide Gel
- GTP-Binding Proteins
- In Vitro Techniques
- Male
- Mice
- Mice, Mutant Strains
- Muscle Contraction