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Article

Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice.

European journal of pharmacology - 15 Jul 2017

Li Zhitao, Singh Sonal, Suryavanshi Santosh V, Ding Wengang, Shen Xiaoxu, Wijaya Cori S, Gao Wei Dong, McConnell Bradley K

Abstract excerpt

Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β2-adrenergic receptor (β2-AR), protein phosphatase 2B and protein kinase C. Gravin facilitates β2-AR-dependent signal transduction through PKA to modulate cardiac excitation-contraction coupling and its removal positively affects cardiac contraction. Trabeculae from the right ventricles of gravin mutant (gravin-t/t) mice were...

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Identifiers

PMID: 28428008
DOI: 10.1016/j.ejphar.2017.04.020
PMCID: PMC5490489

Genes

AKAP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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