Article
Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular dystrophy.
Muscle & nerve - 1 Oct 2002
Chu Victor, Otero Jose M, Lopez Orlando, Sullivan Matthew F, Morgan James P, Amende Ivo, Hampton Thomas G
Abstract excerpt
The mdx mouse is a model of Duchenne muscular dystrophy (DMD). As many DMD patients die of cardiac failure, we investigated whether mdx mice exhibited clinically relevant cardiac phenotypes. We applied a recently developed method for noninvasively recording electrocardiograms (ECGs) to study male mdx mice (n = 15) and control mice (n = 15). The mdx mice had significant tachycardia and decreased heart rate...
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