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Article

Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling.

PloS one - 1 Jan 2011

Olojo Rotimi O, Ziman Andrew P, Hernández-Ochoa Erick O, Allen Paul D, Schneider Martin F, Ward Christopher W

Abstract excerpt

In skeletal muscle, the release of calcium (Ca(2+)) by ryanodine sensitive sarcoplasmic reticulum (SR) Ca(2+) release channels (i.e., ryanodine receptors; RyR1s) is the primary determinant of contractile filament activation. Much attention has been focused on calsequestrin (CASQ1) and its role in SR Ca(2+) buffering as well as its potential for modulating RyR1, the L-type Ca(2+) channel (dihydropyridine receptor,...

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Source

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Identifiers

PMID: 22164205
DOI: 10.1371/journal.pone.0027036
PMCID: PMC3229475

Genes

CASQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling.PMID 22164205Read ↗

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