Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2002

Borrego Francisco, Kabat Juraj, Sanni Tolib B, Coligan John E

Abstract excerpt

Human CD94/NKG2A is an inhibitory receptor that recognizes HLA-E and is expressed by NK cells and a subset of T cells. We have analyzed the cellular trafficking of the CD94/NKG2A receptor using the NKL cell line and peripheral blood NK cells. Flow cytometric, confocal microscopic, and biochemical analyses show that CD94/NKG2A continuously recycles in an active process that requires the cytoskeleton between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Compartmentation
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-E Antigens

Share to Killer Cells, Natural

Share to Lectins, C-Type

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Receptors, Immunologic

Share to Receptors, Natural Killer Cell

Source

Identifiers

PMID: 12444112
DOI: 10.4049/jimmunol.169.11.6102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes.PMID 12444112Read ↗

Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.Semantic proximity Read ↗

Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.Semantic proximity Read ↗

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.Semantic proximity Read ↗

The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E RecognitionSemantic proximity Read ↗

Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.Semantic proximity Read ↗

A Truncated Human NKG2D Splice Isoform Negatively Regulates NKG2D-Mediated FunctionSemantic proximity Read ↗

NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease.Semantic proximity Read ↗

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cellsSemantic proximity Read ↗

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies.Semantic proximity Read ↗

Functional inhibitory human leucocyte antigen class I receptors on natural killer (NK) cells in patients with chronic NK lymphocytosis.Semantic proximity Read ↗

Human NKG2A overrides NKG2C effector functions to prevent autoreactivity of NK cells.Semantic proximity Read ↗

Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.