Article
Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas.
Cancer research - 15 Nov 2000
Huang S C, Koch C A, Vortmeyer A O, Pack S D, Lichtenauer U D, Mannan P, Lubensky I A, Chrousos G P, Gagel R F, Pacak K, Zhuang Z
Abstract excerpt
Inherited mutations of the RET proto-oncogene are tumorigenic in patients with multiple endocrine neoplasia type 2 (MEN 2). However, it is not understood why only few of the affected cells in the target organs develop into tumors. Genetic analysis of nine pheochromocytomas from five unrelated patients with MEN 2 showed either duplication of the mutant RET allele in trisomy 10 or loss of the wild-type RET allele....
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