Article
mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts.
Oncogene - 17 Oct 1996
McMasters K M, Montes de Oca Luna R, Peña J R, Lozano G
Abstract excerpt
The mdm2 gene encodes a protein that is necessary for the negative regulation of p53 function in vivo. Deletion of the mdm2 gene in mice results in early embryonic death while concomitant mdm2 and p53 deletion results in viable offspring. The viability of these mice prompted us to ask if MDM2 had an important growth regulatory function independent of p53. We established mouse embryo fibroblasts null for both p53...
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