Article
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 1996
Jones S N, Sands A T, Hancock A R, Vogel H, Donehower L A, Linke S P, Wahl G M, Bradley A
Abstract excerpt
The Mdm2 oncoprotein forms a complex with the p53 tumor suppressor protein and inhibits p53-mediated regulation of heterologous gene expression. Recently, Mdm2 has been found to bind several other proteins that function to regulate cell cycle progression, including the E2F-1/DP1 transcription factor complex and the retinoblastoma tumor-suppressor protein. To determine whether Mdm2 plays a role in cell cycle...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.