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Article

Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.

Molecular biology of the cell - 1 Nov 1998

Ye X S, Fincher R R, Tang A, Osmani A H, Osmani S A

Abstract excerpt

Surprisingly, although highly temperature-sensitive, the bimA1(APC3) anaphase-promoting complex/cyclosome (APC/C) mutation does not cause arrest of mitotic exit. Instead, rapid inactivation of bimA1(APC3) is shown to promote repeating oscillations of chromosome condensation and decondensation, activation and inactivation of NIMA and p34(cdc2) kinases, and accumulation and degradation of NIMA, which all...

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Identifiers

PMID: 9802893
DOI: 10.1091/mbc.9.11.3019
PMCID: PMC25582

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APC

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Related research

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Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.PMID 9802893Read ↗

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Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from MitosisSemantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.Semantic proximity Read ↗

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