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p53 Immunohistochemical Staining and TP53 Gene Mutations in Endometrial Cancer: Does Null Pattern Correlate With Prognosis?

The American journal of surgical pathology - 1 Oct 2023

Sakamoto Ikuko, Kagami Keiko, Nozaki Takahiro, Hirotsu Yosuke, Amemiya Kenji, Oyama Toshio, Omata Masao

Abstract excerpt

Whether immunohistochemistry (IHC) of p53 accurately reflects the TP53 mutational status of endometrial carcinoma (EC) has not yet been established. This study aimed to clarify the relationship between p53 IHC and TP53 mutations in EC and to examine whether p53 IHC can be a more convenient prognostic marker than TP53 mutation in EC. We performed p53 IHC staining of EC samples obtained via surgery and genetic...

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PMID: 37528644
DOI: 10.1097/PAS.0000000000002106

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