Article
[Phenotypic and functional characterization of cloned T-lymphocytes from cerebrospinal fluid of patients with multiple sclerosis].
Rivista di neurologia - 1 Jan 2000
Barnaba V, Benvenuto R, Buttinelli C, Salvetti M, Toma L, Fiori P
Abstract excerpt
T cell clones derived from the cerebrospinal fluid of patients with multiple sclerosis were investigated for their ability to produce IL2, IL4, IFN gamma and TNF alpha. As controls, liver infiltrating T lymphocyte clones from patients with chronic active hepatitis were used. All CSF clones (both CD4+ and CD8+) produced high amounts of IFN gamma and particularly of TNF alpha. TNF was synthesized in a significantly...
Topics
- Adult
- Cell Division
- Cerebrospinal Fluid
- Clone Cells
- Cytokines
- Cytotoxicity Tests, Immunologic
- Humans
- Multiple Sclerosis
- Phenotype
- T-Lymphocytes