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Article

Transforming Growth Factor–β Antagonizes Alveolar Type II Cell Proliferation Induced by Keratinocyte Growth Factor

27 Aug 2004

Abstract excerpt

Keratinocyte growth factor (KGF) is a mitogen for rat type II cells and also stimulates differentiation in vitro. Administration of KGF also protects the lung from a variety of injuries and subsequent development of fibrosis. Because transforming growth factor (TGF)-beta has been shown to inhibit epithelial cell proliferation and surfactant protein gene expression in other systems and is thought to be a major...

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Identifiers

PMID: 15333329
DOI: 10.1165/rcmb.2004-0182oc

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