Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells.

doi:10.1111/j.1349-7006.1996.tb00233.x

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Article

Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells.

Japanese journal of cancer research : Gann - 1 Apr 1996

Akagi M, Yasui W, Akama Y, Yokozaki H, Tahara H, Haruma K, Kajiyama G, Tahara E

Abstract excerpt

Cell cycle regulators such as cyclins, cyclin-dependent kinases (cdks) and their inhibitors control the growth of cells. SDI1/CIP1/WAF1/p21 is a potent inhibitor of G1 cdks, whose expression is induced by wild-type p53. To elucidate the mechanism of growth inhibition by transforming growth factor...

Topics

Adenocarcinoma
CDC2-CDC28 Kinases
Cell Division
Cyclin E
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases
Cyclins
Genes, Retinoblastoma
Humans
Mutation
Phosphorylation
Protein Serine-Threonine Kinases
RNA, Messenger

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Transforming Growth Factor beta

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 8641969
DOI: 10.1111/j.1349-7006.1996.tb00233.x
PMCID: PMC5921106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8641969-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.