Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells.

Japanese journal of cancer research : Gann - 1 Apr 1996

Akagi M, Yasui W, Akama Y, Yokozaki H, Tahara H, Haruma K, Kajiyama G, Tahara E

Abstract excerpt

Cell cycle regulators such as cyclins, cyclin-dependent kinases (cdks) and their inhibitors control the growth of cells. SDI1/CIP1/WAF1/p21 is a potent inhibitor of G1 cdks, whose expression is induced by wild-type p53. To elucidate the mechanism of growth inhibition by transforming growth factor beta 1 (TGFbeta 1), we examined the effect of TGFbeta 1 on the expression of p21, G1 cyclins and cdks by human gastric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Protein Serine-Threonine Kinases

Share to RNA, Messenger

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 8641969
DOI: 10.1111/j.1349-7006.1996.tb00233.x
PMCID: PMC5921106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells.PMID 8641969Read ↗

p21 (WAF1/CIP1) Mediates the Growth Response to TGF-b in Human Epithelial CellsSemantic proximity Read ↗

p130 mediates TGF-beta-induced cell-cycle arrest in Rb mutant HT-3 cells.Semantic proximity Read ↗

RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.Semantic proximity Read ↗

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancerSemantic proximity Read ↗

Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.Semantic proximity Read ↗

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.Semantic proximity Read ↗

Smad pathway‐specific transcriptional regulation of the cell cycle inhibitor p21<sup>WAF1/Cip1</sup>Semantic proximity Read ↗

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.Semantic proximity Read ↗

Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway.Semantic proximity Read ↗

Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulationSemantic proximity Read ↗

A role for transcriptional repression of p21 <sup>CIP1</sup> by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrestSemantic proximity Read ↗

Association between endogenous gene expression and growth regulation induced by TGF-β1 in human gastric cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.