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Article

Requirements for perpendicular helix pairing.

Proteins - 1 Sept 1996

Beasley J R, Pielak G J

Abstract excerpt

Cassette mutagenesis was used to produce a library of mutations at the interface of the N- and C-terminal helices of Saccharomyces cerevisiae iso-1-cytochrome c. The library is random and comprises > 98% mutations. Over 11,000 candidates were assayed for function by selecting for the ability of yeast, with the mutated gene as their sole cytochrome c source, to grow on nonfermentable carbon sources. We estimate...

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PMID: 8880933
DOI: 10.1002/(SICI)1097-0134(199609)26:1<95::AID-PROT9>3.0.CO;2-F

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