Article
Contributions of the Prion Protein Sequence, Strain, and Environment to the Species Barrier.
The Journal of biological chemistry - 15 Jan 2016
Sharma Aditi, Bruce Kathryn L, Chen Buxin, Gyoneva Stefka, Behrens Sven H, Bommarius Andreas S, Chernoff Yury O
Abstract excerpt
Amyloid propagation requires high levels of sequence specificity so that only molecules with very high sequence identity can form cross-β-sheet structures of sufficient stringency for incorporation into the amyloid fibril. This sequence specificity presents a barrier to the transmission of prions between two species with divergent sequences, termed a species barrier. Here we study the relative effects of protein...
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