Exploring the interface between the N- and C-terminal helices of cytochrome c by random mutagenesis within the C-terminal helix.

doi:10.1021/bi00054a026

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Article

Exploring the interface between the N- and C-terminal helices of cytochrome c by random mutagenesis within the C-terminal helix.

Biochemistry - 26 Jan 1993

Fredericks Z L, Pielak G J

Abstract excerpt

Buried within cytochrome c lies a highly-conserved helix-helix interface formed by the perpendicular packing of the C-terminal helix against the N-terminal helix. This interface involves a peg-in-hole interaction between Gly-6 and Leu-94 and an aromatic-aromatic interaction between Phe-10 and Tyr...

Topics

Amino Acid Sequence
Base Composition
Base Sequence
Codon
Cytochrome c Group
Cytochromes c
DNA Mutational Analysis
Gene Library
Genetic Variation
Molecular Sequence Data
Monte Carlo Method
Protein Structure, Secondary
Protein Structure, Tertiary
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 8380714
DOI: 10.1021/bi00054a026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8380714-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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