Article
Rational design of a more stable yeast iso-1-cytochrome c.
Biochimica et biophysica acta - 15 Jun 1999
Lett C M, Rosu-Myles M D, Frey H E, Guillemette J G
Abstract excerpt
Yeast iso-1-cytochrome c is one of the least stable mitochondrial cytochromes c. We have used a coordinated approach, combining the known functional and structural properties of cytochromes c, to engineer mutations into yeast iso-1-cytochrome c with the goal of selectively increasing the stability of the protein. The two redox forms of the native protein and six different mutant forms of yeast iso-1-cytochrome c...
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