Article
Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice.
The Journal of experimental medicine - 1 Oct 1996
Screpanti I, Musiani P, Bellavia D, Cappelletti M, Aiello F B, Maroder M, Frati L, Modesti A, Gulino A, Poli V
Abstract excerpt
Castleman's disease is a lymphoproliferative disorder thought to be related to deregulated production of IL-6. We have previously shown that mice lacking the trans-acting factor C/EBP beta, a transcriptional regulator of IL-6 and a mediator of IL-6 intracellular signaling, develop a pathology nearly identical to multicentric Castleman's disease, together with increasingly high levels of circulating IL-6. We...
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