Article
Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis.
The Journal of experimental medicine - 21 Sept 1998
Zhang P, Iwama A, Datta M W, Darlington G J, Link D C, Tenen D G
Abstract excerpt
Cytokines stimulate granulopoiesis through signaling via receptors whose expression is controlled by lineage-specific transcription factors. Previously, we demonstrated that granulocyte colony-stimulating factor (G-CSF) receptor mRNA was undetectable and granulocyte maturation blocked in CCAAT en...
Topics
- Animals
- CCAAT-Enhancer-Binding Proteins
- Cell Differentiation
- Colony-Forming Units Assay
- DNA-Binding Proteins
- Drug Synergism
- Enhancer Elements, Genetic
- Fetus
- Granulocytes
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Interleukin-6
- Liver