Article

Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model

2026-07-29

Abstract excerpt

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder that affects lymph nodes at multiple sites and can progress to life-threatening organ dysfunction. While curative therapies remain unavailable, largely due to a critical gap in understanding the disease’s underlying etiology, the cytokine interleukin-6 (IL-6) is recognized as a major pathogenic driver, particularly in iMCD pati...

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Literature Corpus work: a4bdbbf5-83d6-5551-8ec7-b0ed94c72569
DOI: 10.64898/2026.07.26.740764

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