Article
Deletion of signaling molecule genes resembling the cytoplasmic domain of Igbeta in autoimmune-prone mice.
International immunology - 1 Jun 1998
Maeda T, Webb D R, Chen J, Kobata T, Hirose S, Shirai T, Takabayashi K, Nishioka K, Sumida T
Abstract excerpt
The P8.6 gene is encoded upstream of the mouse TCR Valpha1 gene in the anti-sense strand and its gene product contains the proline-rich region and tyrosine-isoleucine (Y-I) motif, which are consensus sequences for the SH2 and SH3 binding motifs respectively. It was found that this protein is high...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Autoimmunity
- Base Sequence
- Blotting, Southern
- Blotting, Western
- CD79 Antigens
- Carrier Proteins
- Cloning, Molecular
- Gene Deletion
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred MRL lpr
- Mice, Inbred NZB
- Molecular Sequence Data
- Mutation