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Article

Detection and quantitation of cells secreting IL-6 under physiologic conditions in BALB/c mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1993

Shirai A, Holmes K, Klinman D

Abstract excerpt

IL-6 is a pleiotropic cytokine involved in the regulation of hematopoiesis and lymphocyte activation. An extremely sensitive ELIspot assay was developed to detect and enumerate individual cells secreting IL-6 in normal BALB/c mice. Under physiologic conditions, the frequency of cells producing IL-6 in the bone marrow, spleen, and mesenteric lymph nodes of normal adult animals was approximately 0.5, 0.1, and...

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PMID: 8423340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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