Detection and quantitation of cells secreting IL-6 under physiologic conditions in BALB/c mice.

Article

Detection and quantitation of cells secreting IL-6 under physiologic conditions in BALB/c mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1993

Shirai A, Holmes K, Klinman D

Abstract excerpt

IL-6 is a pleiotropic cytokine involved in the regulation of hematopoiesis and lymphocyte activation. An extremely sensitive ELIspot assay was developed to detect and enumerate individual cells secreting IL-6 in normal BALB/c mice. Under physiologic conditions, the frequency of cells producing IL...

Topics

Animals
Bone Marrow
Enzyme-Linked Immunosorbent Assay
Interleukin-6
Lymph Nodes
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Phenotype
Spleen

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