Article
Cell-substratum interactions mediate oncogene-induced phenotype of lung cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1996
Barr L F, Campbell S E, Penno M B, Ball D W, Baylin S B
Abstract excerpt
In vivo and in vitro studies have linked small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) cells along a differentiation continuum. The transition of a SCLC toward a NSCLC phenotype is modeled in culture by the simultaneous overexpression of myc and ras genes in cultured SCLC cells. A major phenotypic distinction between SCLC and NSCLC in culture is that SCLC cells usually grow in floating...
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