Article
All-trans-retinoic acid alters myc gene expression and inhibits in vitro progression in small cell lung cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1994
Kalemkerian G P, Jasti R K, Celano P, Nelkin B D, Mabry M
Abstract excerpt
Transitions between the small cell lung cancer and the non-small cell lung cancer phenotype occur during clinical tumor progression in small cell lung cancer. We have previously developed a culture model which mimics these transitions. In our model, the insertion of the v-Ha-ras oncogene into c-myc overexpressing NCI-H82 small cell lung cancer cells induces features characteristic of non-small cell lung cancer....
Topics
- Carcinoma, Small Cell
- Gene Expression
- Genes, myc
- Humans
- In Vitro Techniques
- Lung Neoplasms
- Phenotype
- Time Factors
- Tretinoin
- Tumor Cells, Cultured