Article
Transitions between lung cancer phenotypes--implications for tumor progression.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) - 1 Feb 1991
Mabry M, Nelkin B D, Falco J P, Barr L F, Baylin S B
Abstract excerpt
Progression from a treatment-sensitive to a treatment-resistant tumor state is a virtually universal phenomenon in patients with small-cell lung carcinoma (SCLC). In such individuals, this tumor progression may involve transitions from a SCLC to a non-SCLC lung cancer phenotype. We are investigating the cell and molecular biology aspects of these transitions and have derived a cell culture model of one such...
Topics
- Bronchial Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Cell Differentiation
- Epithelium
- Humans
- Lung Neoplasms
- Models, Biological
- Phenotype
- Tumor Cells, Cultured