Article
Transitions between lung cancer phenotypes--implications for tumor progression.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) - 1 Feb 1991
Mabry M, Nelkin B D, Falco J P, Barr L F, Baylin S B
Abstract excerpt
Progression from a treatment-sensitive to a treatment-resistant tumor state is a virtually universal phenomenon in patients with small-cell lung carcinoma (SCLC). In such individuals, this tumor progression may involve transitions from a SCLC to a non-SCLC lung cancer phenotype. We are investigating the cell and molecular biology aspects of these transitions and have derived a cell culture model of one such...
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