Article
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Science (New York, N.Y.) - 8 Nov 1996
Gorina S, Pavletich N P
Abstract excerpt
Mutations in the p53 tumor suppressor are among the most frequently observed genetic alterations in human cancer and map to the 200-amino acid core domain of the protein. The core domain contains the sequence-specific DNA binding activity and the in vitro 53BP2 protein binding activity of p53. The crystal structure of the p53 core domain bound to the 53BP2 protein, which contains an SH3 (Src homology 3) domain...
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