Article
Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.
The Journal of biological chemistry - 13 Apr 2001
Zhao K, Chai X, Johnston K, Clements A, Marmorstein R
Abstract excerpt
The p53 tumor suppressor is a sequence-specific DNA-binding protein that activates transcription in response to DNA damage to promote cell cycle arrest or apoptosis. The p53 protein functions in a tetrameric form in vivo and contains four domains including an N-terminal transcriptional activation domain, a C-terminal regulatory domain, a tetramerization domain, and a central core DNA-binding domain that is the...
Topics
- Animals
- Binding Sites
- Crystallography, X-Ray
- DNA
- Dimerization
- Humans
- Mice
- Models, Molecular
- Mutation
- Protein Conformation
- Static Electricity
- Tumor Suppressor Protein p53