Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hADA3 is required for p53 activity.

The EMBO journal - 15 Nov 2001

Wang T, Kobayashi T, Takimoto R, Denes A E, Snyder E L, el-Deiry W S, Brachmann R K

Abstract excerpt

The tumor suppressor protein p53 is a transcription factor that is frequently mutated in human cancers. In response to DNA damage, p53 protein is stabilized and activated by post-translational modifications that enable it to induce either apoptosis or cell cycle arrest. Using a novel yeast p53 dissociator assay, we identify hADA3, a part of histone acetyltransferase complexes, as an important cofactor for p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Antibiotics, Antineoplastic
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Share to Histone Acetyltransferases

Share to Oligonucleotides, Antisense

Share to Precipitin Tests

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 11707411
DOI: 10.1093/emboj/20.22.6404
PMCID: PMC125723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

hADA3 is required for p53 activity.PMID 11707411Read ↗

An essential role of human Ada3 in p53 acetylation.Semantic proximity Read ↗

Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3Semantic proximity Read ↗

TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its functionSemantic proximity Read ↗

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.Semantic proximity Read ↗

E2F3 Is a Mediator of DNA Damage-Induced ApoptosisSemantic proximity Read ↗

The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.Semantic proximity Read ↗

Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Promoters in Response to Genotoxic StressSemantic proximity Read ↗

A Genetic Screen Identifies TCF3/E2A and TRIAP1 as Pathway-Specific Regulators of the Cellular Response to p53 ActivationSemantic proximity Read ↗

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].Semantic proximity Read ↗

SETD3 is a positive regulator of DNA-damage-induced apoptosisSemantic proximity Read ↗

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.Semantic proximity Read ↗

The ASPP family: deciding between life and death after DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.