Article
Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein.
Human mutation - 1 Feb 2002
Martin Andrew C R, Facchiano Angelo M, Cuff Alison L, Hernandez-Boussard Tina, Olivier Magali, Hainaut Pierre, Thornton Janet M
Abstract excerpt
TP53 encodes p53, which is a nuclear phosphoprotein with cancer-inhibiting properties. In response to DNA damage, p53 is activated and mediates a set of antiproliferative responses including cell-cycle arrest and apoptosis. Mutations in the TP53 gene are associated with more than 50% of human cancers, and 90% of these affect p53-DNA interactions, resulting in a partial or complete loss of transactivation...
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