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Article

New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain.

Laboratory animal science - 1 Aug 1996

Ishigaki Y, Hayakawa J, Hashimoto N, Nikaido H, Nikaido O

Abstract excerpt

We introduced two mutant genes (beige or bg, which induces a deficiency of natural killer activity, and xid, which decreases the production of immunoglobulins) into KSN nude mice with high reproductive performance. At first we produced the KSN-bg/bg(nu/nu) (KSN-bg) and KSN-xid/xid(nu/nu) (KSN-xid) congenic strain by backcross (cross-intercross method). After we identified homozygosity at the biochemical locus and...

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PMID: 8872993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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