New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain.

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Article

New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain.

Laboratory animal science - 1 Aug 1996

Ishigaki Y, Hayakawa J, Hashimoto N, Nikaido H, Nikaido O

Abstract excerpt

We introduced two mutant genes (beige or bg, which induces a deficiency of natural killer activity, and xid, which decreases the production of immunoglobulins) into KSN nude mice with high reproductive performance. At first we produced the KSN-bg/bg(nu/nu) (KSN-bg) and KSN-xid/xid(nu/nu) (KSN-xid...

Topics

Animals
Flow Cytometry
Homozygote
Humans
Immunoglobulins
Immunologic Deficiency Syndromes
Inbreeding
Killer Cells, Natural
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Nude
Microsatellite Repeats
Mutation
Neoplasm Transplantation
Reproduction
Spleen

Source

Open in PubMed

Identifiers

PMID: 8872993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8872993-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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