Article
Development of the Nude Rabbit Model.
Stem cell reports - 9 Mar 2021
Song Jun, Hoenerhoff Mark, Yang Dongshan, Yang Ying, Deng Cheng, Wen Luan, Ma Linyuan, Pallas Brooke, Zhao Changzhi, Koike Yui, Koike Tomonari, Lester Patrick, Yang Bo, Zhang Jifeng, Chen Y Eugene, Xu Jie
Abstract excerpt
Loss-of-function mutations in the forkhead box N1 (FOXN1) gene lead to nude severe combined immunodeficiency, a rare inherited syndrome characterized by athymia, severe T cell immunodeficiency, congenital alopecia, and nail dystrophy. We recently produced FOXN1 mutant nude rabbits (NuRabbits) by using CRISPR-Cas9. Here we report the establishment and maintenance of the NuRabbit colony. NuRabbits, like nude mice,...
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