Article
A novel EGFP-expressing nude mice with complete loss of lymphocytes and NK cells to study tumor-host interactions.
Bioscience trends - 1 Aug 2014
Gotoh Kumiko, Kariya Ryusho, Matsuda Kouki, Hattori Shinichiro, Vaeteewoottacharn Kulthida, Okada Seiji
Abstract excerpt
Enhanced green fluorescent protein (EGFP) expressing Balb/c nude mice strain with Rag-2 and Jak3 double mutants (Nude-R/J-EGFP mice) was established to improve the take rate of human tumors and to distinguish tumor and host cells. EGFP was ubiquitously expressed in all organs including the brain, lung, liver, heart, kidney, spleen, and gastrointestinal tract in Nude-R/J-EGFP mice. The mice showed complete loss of...
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