Article
The nude mutation results in impaired primary antibody repertoire.
European journal of immunology - 1 Feb 1995
Kaushik A, Kelsoe G, Jaton J C
Abstract excerpt
We have studied the effect of the nude mutation and/or T lymphocytes on the development of V gene germ-line repertoire in neonatal athymic (nu/nu) and euthymic (+/nu) littermates. A total of 2.35 x 10(6) and 1.47 x 10(6) B lymphocyte clones from nu/nu and +/nu neonates, respectively, were examined for the expression of select VH (J558, J606, S107, 36-60, 7183 and Q52) and Vx (1, 2, 8 and 9) gene families as well...
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