Article
Identification of cis-acting regions that contribute to neuron-specific expression of the GAP-43 gene.
Bioscience, biotechnology, and biochemistry - 1 Jun 2006
Takahashi Mikio, Sato Yoshitaka, Nakagami Yuki, Miyake Katsuhide, Iijima Shinji
Abstract excerpt
There are two transcription start sites in the growth-associated protein 43 (GAP-43) promoter, and several repressive elements have been reported in the control region. But the repressive effects have been analyzed only for the distal transcription start site. Among the repressive elements reported, we found that modulator I repressed GAP-43 gene expression from the proximal promoter in non-neuronal cells. We...
Topics
- Animals
- Cell Line
- GAP-43 Protein
- Gene Deletion
- Gene Expression Regulation
- Mice
- Mutation
- Neurons
- Promoter Regions, Genetic