Article
Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.
Biophysical journal - 8 Apr 2009
Zhou Yubin, Yang Wei, Lurtz Monica M, Chen Yanyi, Jiang Jie, Huang Yun, Louis Charles F, Yang Jenny J
Abstract excerpt
We have shown previously that the Ca2+-dependent inhibition of lens epithelial cell-to-cell communication is mediated in part by the direct association of calmodulin (CaM) with connexin43 (Cx43), the major connexin in these cells. We now show that elevation of [Ca2+](i) in HeLa cells transfected with the lens fiber cell gap junction protein sheep Cx44 also results in the inhibition of cell-to-cell dye transfer. A...
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