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Article

Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7.

Infection and immunity - 1 May 1999

Govoni G, Canonne-Hergaux F, Pfeifer C G, Marcus S L, Mills S D, Hackam D J, Grinstein S, Malo D, Finlay B B, Gros P

Abstract excerpt

Mutations at the Nramp1 locus in vivo cause susceptibility to infection by unrelated intracellular microbes. Nramp1 encodes an integral membrane protein abundantly expressed in the endosomal-lysosomal compartment of macrophages and is recruited to the phagosomal membrane following phagocytosis. The mechanism by which Nramp1 affects the biochemical properties of the phagosome to control microbial replication is...

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Identifiers

PMID: 10225878
DOI: 10.1128/IAI.67.5.2225-2232.1999
PMCID: PMC115961

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Source receipt: pubmed, retrieved 7 Sept 2026.

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