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Article

The central pseudoknot in 16S ribosomal RNA is needed for ribosome stability but is not essential for 30S initiation complex formation.

Nucleic acids research - 1 Oct 1996

Poot R A, Pleij C W, van Duin J

Abstract excerpt

To examine the function of the central pseudoknot in 16S rRNA, we have studied Escherichia coli 30S subunits with the A18 mutation in this structure element. Previously, this mutation, which changes the central base pair of helix 2, C18--G917, to an A18xG917 mismatch, was shown to inhibit translation in vivo and a defect in initiation was suggested. Here, we find that the mutant 30S particles are impaired in...

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Identifiers

PMID: 8871543
DOI: 10.1093/nar/24.19.3670
PMCID: PMC146175

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