Article
[Mutational pattern of Ig-VH genes of synovial B-lymphocytes from different anatomical locations in a rheumatoid arthritis patient].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1999
Souto-Carneiro M M, Krenn V, Hermann R, Ristow G, König A, Müller-Hermelink H K
Abstract excerpt
Synovial B-lymphocytes which are a constant feature of RA synovialitis are expanded in an antigen dependent manner. To understand the nature of the antigen driving the B-cell expansion it would be interesting to know whether there exists a restricted number of antigens. Therefore the usage of germline genes and the mutational pattern of Ig-VH-genes from synovial B-cells from 3 different anatomical regions with...
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