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Article

Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice.

Science (New York, N.Y.) - 1 Nov 1996

Lindberg F P, Bullard D C, Caver T E, Gresham H D, Beaudet A L, Brown E J

Abstract excerpt

Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous littermates. In vivo, they had an early defect in PMN accumulation at the site of infection. In vitro, IAP-/- PMNs...

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PMID: 8864123
DOI: 10.1126/science.274.5288.795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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