Article
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.
Nature communications - 25 Oct 2016
Ulland Tyler K, Jain Nidhi, Hornick Emma E, Elliott Eric I, Clay Gwendolyn M, Sadler Jeffrey J, Mills Kathleen A M, Janowski Ann M, Volk A Paige Davis, Wang Kai, Legge Kevin L, Gakhar Lokesh, Bourdi Mohammed, Ferguson Polly J, Wilson Mary E, Cassel Suzanne L, Sutterwala Fayyaz S
Abstract excerpt
The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a missense mutation in Nlrp12 in C57BL/6J mice. Both C57BL/6J and NLRP12-deficient mice have increased susceptibility...
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