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Article

SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).

Cell reports - 25 Oct 2012

van Beek Ellen M, Zarate Julian Alvarez, van Bruggen Robin, Schornagel Karin, Tool Anton T J, Matozaki Takashi, Kraal Georg, Roos Dirk, van den Berg Timo K

Abstract excerpt

The phagocyte NADPH oxidase mediates oxidative microbial killing in granulocytes and macrophages. However, because the reactive oxygen species produced by the NADPH oxidase can also be toxic to the host, it is essential to control its activity. Little is known about the endogenous mechanism(s) that limits NADPH oxidase activity. Here, we demonstrate that the myeloid-inhibitory receptor SIRPα acts as a negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23022485
DOI: 10.1016/j.celrep.2012.08.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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