Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.

Nature immunology - 1 Jan 2013

Wang Jing, Shiratori Ikuo, Uehori Junji, Ikawa Masahito, Arase Hisashi

Abstract excerpt

Acute inflammatory responses are important in host defense, whereas dysregulated inflammation results in life-threatening complications. Here we found that paired immunoglobulin-like type 2 receptor alpha (PILRα), an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), negatively regulated neutrophil infiltration during inflammation. Pilra(-/-) mice had increased neutrophil...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Movement
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrins

Share to Intercellular Adhesion Molecule-1

Share to Neutrophils

Share to Receptors, Immunologic

Share to Shock, Septic

Source

Identifiers

PMID: 23142774
DOI: 10.1038/ni.2456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.PMID 23142774Read ↗

β2 Integrin Signaling Cascade in Neutrophils: More Than a Single FunctionSemantic proximity Read ↗

IRF5 controls both acute and chronic inflammationSemantic proximity Read ↗

Inflammatory Monocytes and Subsets of Macrophages with Distinct Surface Phenotype Correlate with Specific Integrin Expression Profile during Murine Sepsis.Semantic proximity Read ↗

Inflammation induces pro-NETotic neutrophils via TNFR2 signalingSemantic proximity Read ↗

The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.Semantic proximity Read ↗

Paired immunoglobulin-like receptor B regulates platelet activation.Semantic proximity Read ↗

Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection.Semantic proximity Read ↗

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and DiseaseSemantic proximity Read ↗

Integrin αDβ2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory SignalingSemantic proximity Read ↗

Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo InfiltrationSemantic proximity Read ↗

Integrin Regulation during Leukocyte RecruitmentSemantic proximity Read ↗

Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.