Article
Importance of integrin LFA-1 deactivation for the generation of immune responses.
The Journal of experimental medicine - 20 Jun 2005
Semmrich Monika, Smith Andrew, Feterowski Carolin, Beer Sandra, Engelhardt Britta, Busch Dirk H, Bartsch Bernadett, Laschinger Melanie, Hogg Nancy, Pfeffer Klaus, Holzmann Bernhard
Abstract excerpt
The dynamic regulation of ligand binding is considered crucial for integrin function. However, the importance of activity regulation for integrin function in vivo is largely unknown. Here, we have applied gene targeting to delete the GFFKR sequence of the lymphocyte function-associated antigen-1 (LFA-1) alpha(L) subunit cytoplasmic domain in mouse germline. Lymphocytes from Lfa-1(d/d) mutant mice showed...
Topics
- Animals
- Antibodies
- Antibody Formation
- Cell Adhesion
- Chromosomes, Artificial, Bacterial
- DNA Primers
- Gene Targeting
- Humans
- Immunity, Cellular
- Intercellular Adhesion Molecule-1