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Article

Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm

19 Sept 2005

Abstract excerpt

Macrolide and ketolide antibiotics inhibit protein synthesis on the bacterial ribosome. Resistance to these antibiotics is conferred by dimethylation at 23S rRNA nucleotide A2058 within the ribosomal binding site. This form of resistance is encoded by erm dimethyltransferase genes, and is found in many pathogenic bacteria. Clinical isolates of Streptococcus pneumoniae with constitutive erm(B) and Streptococcus...

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Share to Infective Endocarditis Diagnosis and Management
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PMID: 16194243
DOI: 10.1111/j.1365-2958.2005.04863.x

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