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Article

Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins.

Science (New York, N.Y.) - 25 Oct 1996

Aitchison J D, Blobel G, Rout M P

Abstract excerpt

A cytosolic yeast karyopherin, Kap104p, was isolated and shown to function in the nuclear import of a specific class of proteins. The protein bound directly to repeat-containing nucleoporins and to a cytosolic pool of two nuclear messenger RNA (mRNA) binding proteins, Nab2p and Nab4p. Depletion of Kap104p resulted in a rapid shift of Nab2p from the nucleus to the cytoplasm without affecting the localization of...

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Identifiers

PMID: 8849456
DOI: 10.1126/science.274.5287.624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins.PMID 8849456Read ↗

Importin/karyopherin protein family members required for mRNA export from the nucleus.Semantic proximity Read ↗

Intersection of the Kap123p-mediated nuclear import and ribosome export pathways.Semantic proximity Read ↗

The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo.Semantic proximity Read ↗

Cell cycle regulated transport controlled by alterations in the nuclear pore complex.Semantic proximity Read ↗

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.Semantic proximity Read ↗

Yeast karyopherin Kap95 is required for cell cycle progression at Start.Semantic proximity Read ↗

A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.Semantic proximity Read ↗

The mitogen-activated protein kinase Slt2 regulates nuclear retention of non-heat shock mRNAs during heat shock-induced stress.Semantic proximity Read ↗

Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p.Semantic proximity Read ↗

The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein.Semantic proximity Read ↗

The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.Semantic proximity Read ↗

A role for the karyopherin Kap123p in microtubule stability.Semantic proximity Read ↗

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