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Article

A role for the karyopherin Kap123p in microtubule stability.

Traffic (Copenhagen, Denmark) - 1 Nov 2009

Ptak Christopher, Anderson Andrea M, Scott Robert J, Van de Vosse David, Rogers Richard S, Sydorskyy Yaroslav, Aitchison John D, Wozniak Richard W

Abstract excerpt

Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule-destabilizing drugs. One mutant exhibiting this phenotype lacked the gene encoding the karyopherin Kap123p. Analysis of...

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Identifiers

PMID: 19761543
DOI: 10.1111/j.1600-0854.2009.00978.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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